Gestational Trophoblastic Disease-a Strangely Abnormal Pregnancy

20.12.18

Hello friends,

As this topic ‘Gestational Trophoblastic Disease’ is a vast topic and we want to bring understanding to this topic in as simple a language as possible such that it can be easily understood by everyone,we are starting an article series.The introductory article will give you a glimpse about how will we go about it.

Let’s start

-Gestational trophoblastic disease or GTD refers to a spectrum of interrelated but histologically distinct tumors originating from the placenta.

– These diseases are characterized by a reliable tumors marker beta HCG   and have varying tendencies towards local invasion and spread.

-Gestational trophoblastic neoplasia or GTN refers to the subset that develops malignant and cancerous sequelae.

-We will discuss incidence and risk factors of GTD.

– Hydatidiform mole or molar pregnancy is the subset which is benign or non- cancerous in nature.

-It is divided into two complete and partial hydatidiform mole. In this discussion we will see karyotype pattern, microscopic and macroscopic findings and clinical findings.

– Diagnosis of  mole is usually done by beta HCG estimation, trans- vaginal sonography and histopathology.

– Management requires suction evacuation of molar pregnancy and post molar surveillance by serial beta HCG level estimation. We will have a discussion on that.

-Gestational trophoblastic neoplasia include

-Invasive mole

-Gestational  choriocarcinoma

-Placenta like trophoblastic tumor and

-Epithelioid trophoblastic tumor

We will discuss criteria for diagnosis of GTN and their individual features.

– Most GTN cases are clinically diagnosed based on beta HCG levels.Tissue histology is also used.

-After diagnosis patients with GTN undergo thorough pre-treatment assessment including CT scan.

-Staging is done as per Gynaec society and WHO guidelines.

-This disease is divided into non-metastatic and metastatic disease.

– Treatment of GTN is either surgical or with chemotherapy.

-We will also discuss psychological consequences and subsequent pregnancy outcome of this disease.

-So, friends you do get an idea of what all things we will cover under this topic ‘Gestational Trophoblastic Disease’

-In next update of article of this series we will take one of the above listed topics and bring more clarity on that

-Keep a watch on this article itself as a dated update will arrive soon.