Pre-Cancerous Lesions of the Lower Genital Tract of Women


Hello friends,

As this topic ‘Preinvasive/Pre-Cancerous Lesions of the Lower Genital Tract of Women’ is a vast topic and we want to bring understanding to this topic in as simple a language as possible such that it can be easily understood by everyone,we are starting an article series.

The introductory article will give you a glimpse about how will we go about it.

Let’s start

-Pre-invasive lesions of the genital tract also is referred to as intraepithelial neoplasia which essentially means that the pathology or lesions are diagnosed by biopsy and histologic evaluation.

– These lesions include squamous epithelium or superficial surfaces of cervix, vagina, vulva, perineum and anus.

-In this series we will talk about the grading of these lesions and their terminology.

-In brief we will discuss pathology of external genitalia and vagina.

– However, we will discuss in detail the pathology involving cervix.

– I would like to mention that the formation and dynamics of cervix is such that squamo-columnar junction plays a big part in its pathology.

– This junction undergoes changes depending upon age, hormonal status and many other factors which we will discuss.

– Transformation zone which is the origin point of cervical cancer usually lies near to squamo-columnar junction. We will discuss relation between them.

-Human papilloma virus also known as HPV is the causative factor of cervical cancer.

-About HPV we will discuss its life cycle, types of virus, HPV transmission, outcome, natural history, diagnosis, treatment and prevention of HPV infection.

-While discussing cervical intraepithelial neoplasia we will talk about it incidence, natural history and risk factors.

-For its diagnosis cervical cytology also popularly known as Pap’s smear, HPV testing and colposcopy is used. We will discuss the guidelines and various procedures involved.

-Biopsy means microscopic evaluation of a piece of cervix. We will discuss its procedure.

-In management of cervical intraepithelial neoplasia, we will discuss ablative and excisional methods along with post treatment surveillance.

-For lesion involving vagina, vulva and anus we will discuss their pathophysiology, risk factors, diagnosis, treatment and prognosis.

-So, friends you do get an idea of what all things we will cover under this topic ‘Preinvasive/Precancerous Lesions of The Lower Genital Tract of Women’

-In next update of article of this series we will take one of the above listed topics and bring more clarity on that

-Keep a watch on this article itself as a dated update will arrive soon.